The Hypoglycemic Effects of an Ethanol Extract of Peganum harmala in Streptozotocin-Induced Diabetic Rats

Authors

  • Ali Ramazani Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan-Iran Biotechnology Departments, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan - Iran.
  • Hamid Reza Kheiri Manjili Pharmaceutical Nanotechnology, Department, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  • Hossein Danafar Medicinal Chemistry Department, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan - Iran.
  • Koorosh Foladsaz Biochemistry Departments, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan-Iran
Abstract:

Peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. Moreover, it is used to treat a variety of human ailments, including depression. This study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. A hydro alcoholic extract from seeds of this herb was prepared and administered at three doses of 30, 60 and 120 mg/kg to three groups of streptozotocin-induced diabetic rats. Two additional groups were used as negative (normal saline plus solvent) and positive control (metformin). Blood glucose levels in animals from all groups were measured at 2, 4, and 6 hours after intraperitoneal injection of the extract to rats. Blood glucose levels decreased in the diabetic rats in comparison with normal rats (P < 0.05). Our finding showed that P. harmala seed extract has good antidiabetic activity in streptozotocin-induced diabetic rats. Further studies need to isolate active compounds and to investigate their activity.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the hypoglycemic effects of an ethanol extract of peganum harmala in streptozotocin-induced diabetic rats

peganum harmala is a plant that is traditionally used as an analgesic, anti-inflammatory, antibacterial, antioxidant, anti-helmintic, and antimutagenic agent. moreover, it is used to treat a variety of human ailments, including depression. this study was conducted to investigate the antidiabetic activity of hydro alcoholic extract of this herb. a hydro alcoholic extract from seeds of this herb ...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Hypoglycemic Effects of Nigella Sativa Extract and Endurance Training in Streptozotocin Induced Diabetic Rats

Objective: Diabetes is a common disease and its prevalence rate is rapidly increasing. Aim of present study was to review the hypoglycemic effects of Nigella sativa (N.sativa) extract and endurance training in streptozotocin induced diabetic rats. Materials and Methods: In this experimental research from 50 streptozotocine induced diabetic rats, 32 rats with more than 300 mg/dL fasting blood g...

full text

Hypoglycemic, and hypolipidemic effect of Smyrnium cordifolium Boiss extract in streptozotocin induced diabetic male rats

مقدمه و هدف: دیابت یکی از شایع ترین بیماری های قرن حاضر است. در این پژوهش تاثیر عصاره هیدروالکلی گیاه آوندول بر رت‌های دیابتی مورد بررسی قرار گرفت. روش تحقیق:در این مطالعه تجربی، ۴۰ سر رت نژاد ویستار به طور تصادفی به 5 گروه یکسان تقسیم شدند. گروه 1 (کنترل سالم): رت‌هایی سالم و غیر دیابتی که در شرایط نوری، آب و غذا...

full text

Hypoglycemic, and hypolipidemic effect of Smyrnium cordifolium Boiss extract in streptozotocin induced diabetic male rats

مقدمه و هدف: دیابت یکی از شایع ترین بیماری های قرن حاضر است. در این پژوهش تاثیر عصاره هیدروالکلی گیاه آوندول بر رت‌های دیابتی مورد بررسی قرار گرفت. روش تحقیق:در این مطالعه تجربی، ۴۰ سر رت نژاد ویستار به طور تصادفی به 5 گروه یکسان تقسیم شدند. گروه 1 (کنترل سالم): رت‌هایی سالم و غیر دیابتی که در شرایط نوری، آب و غذا...

full text

Effects of ethanol extract of Salvia hydrangea on hepatic and renal functions of streptozotocin-induced diabetic rats

Objectives: A wide range of liver and kidney disorders are associated with diabetes and there is a mutual relationship between diabetes and these diseases. Herbal medicine with having abundant ingredients is one of these options. The goal of this study was to compare the effects of alcoholic extract of aerial parts of Salvia hydrangea with glibenclamide on functional tests of liver and kidney i...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 10  issue 3

pages  47- 54

publication date 2014-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023